Course Plan

(Spring Semester)

CBCT

  

BE-522: Basic Neuro-engineering (CBCT)

The integration of biomolecules with electronic elements to yield functional devices attracts substantial research efforts because of the basic fundamental scientific questions and the potential practical applications of the systems. The research field gained the buzzword "bioelectronics" aimed at highlighting that the world of electronics could be cross fertilized with biology and biotechnology. The major activities in the field of bioelectronics relate to the development of biosensors that transduce biorecognition or biocatalytic processes in the form of electronic signals. Neuroengineering, or more precisely Bio-neuroengineering which is inseparable part of Bioelectronics, is an interdisciplinary area, with the common goal of analyzing the function of the nervous system, developing methods to restore damaged neurological function & creating artificial neuronal systems by integrating physical, chemical, mathematical & engineering tools. The development of artificial circuit models that simulate the behavior of biological neuron is one of today's most promising directions of investigation in the field of neurobio and neuromorphic engineering.

Objective vis-a-vis Lecture Modules

Modules

Topic Learning Objectives

1

Introduction

Biology of the neuron, Biophysical description of the action potential, Synapses

2

Membrane

Membrane transport, Membrane capacitance

3

Hodgkin-Huxley (H-H) Model

H-H model of membrane, Membrane currents, Cable equation.

4

Myelinated Nerve

Electric circuit model of myelinated nerve

5

Neural modeling

Linear dendritic model, Varicosities & impulse conduction, Information processing in dendrites

6

Silicon model of neuron

H-H model, synapse model, simple neuron logic gates.

7

Neuronal networks

Neuronal networks, Neural coding

Prerequisites of the course

Basic understanding of Biology, Physiology of human body and basic knowledge of electronics is desired but not essential.  

Lecture Plan

Tentative Lecture Topics

1

Introduction

2-3

Biology of the neuron

4-5

Biophysical description of the action potential

6-8

Synapses: Chemical Synapse, Electrical circuit model of synapse

9

Membrane transport

10

Membrane capacitance

11- 12

Hodgkin-Huxley (H-H) Model of membrane

13-14

Membrane currents

15-16

Cable equation

17

Myelinated Nerve

18-19

Electric circuit model of myelinated nerve

20-21

Neural modeling: Linear dendritic model

22-23

Varicosities & impulse conduction

24-25

Information processing in dendrites

26-27

Silicon model of neuron: H-H model

28-29

Synapse model, simple neuron logic gates

30-31

Neuronal networks

32-33

Neural coding
Pedagogy

Class Room Lectures
Presentations
Seminars
Assignments
Group assignments

 

Expected outcome

After completing the course BE 522, student is expected to have the basic knowledge of the Bio neuro-engineering and students are expected to work in the field of Bio-neuro-engineering as project work or as per their interest.

 

Text/Reference Book

1. Grattarola, M. Massobrio, G. Bioelectronics Handbook, MOSFETs, Biosensors & Neurons; McGraw Hill
2. Nicholls, J. C. Martin, A R Wallace, B. G. From Neuron to Brain; Sinauer Associates
3. Mead, C. Analog VLSI and Neural Systems; Addison Wesley

4. Metin, A. Neural Engineering; Wiley/IEEE Press,Vol 1-6