ANUPAM NATH JHA

Academic Profile

Ph. D. (Computational Biophysics) in 2010 from Molecular Biophysics Unit (MBU), Indian Institute of Science (IISc), Bangalore .
M. Sc. (Physics) in 2004 from Banaras Hindu University (BHU), Varanasi, India.
B.Sc. (Physics (Hons)) in 2002 from Banaras Hindu University (BHU), Varanasi, India.

Positions held:

Assistant Professor (Grade III), Department of Molecular Biology and Biotechnology (MBBT), Tezpur University, September 2020 to till date
Assistant Professor (Grade II), Department of Molecular Biology and Biotechnology (MBBT), Tezpur University, 2015 to 2020
Assistant Professor (Grade I), Department of Molecular Biology and Biotechnology (MBBT), Tezpur University, 2011 to 2015.
Post Doctoral Fellow, National Center for Biological Sciences (NCBS), Bangalore, Jan - Aug 2011.

Honors/Awards:

International Travel award for the poster presentation in Biophysical Society 54^th Annual Meeting in San Francisco, California USA 2010
Indian Institute of Science (IISc, Bangalore) Research Fellowship Award towards PhD (2004-2009)
Council for Scientific and Industrial Research (CSIR-NET), Government of India 2004
AIR (82) with 96.4 percentile in Physics subject in GATE (Graduate Aptitude Test in Engineering) conducted by Department of Education, Government of India 2003
Ranked in top 97.4 percentile of candidates from Physics in JEST (Joint Entrance Screening Test) 2003

Research Interest:

Computational Biophysics, Bioinformatics, Systems Biology.

Research Group:

PhD Students

Mr Debanjan Saha, M.Sc Life Science and Bioinformatics, PhD (July 2019 - Present)
Ms Upasana Hazarika, M.Sc Biophysics, PhD (July 2020 - Present)
Mr Ajit Kr Singh, M.Sc Bioinformatics, PhD (July 2021 - Present)
Ms Sibasree Hojaisa, M.Sc Life Science, PhD (July 2022 - Present)

Project Staff

Mr Nayan Jyoti Borah, Int MSc 2023 -->

Research Project:

A) On-going

#	Title	Funding Agency	Duration (in Years)	Amount (in Lakhs)
	Integrated WGS and metabolic pathway analysis for SNPs related to drug resistance for targeted drug development	ICMR, Govt. of India	2	23
	Strategic Systems Biology and Metabolic Pathways approach to develop nanocarriers for targeted drug delivery	SERB-DST, Govt. of India	3	26

B) Completed

Title	Collaborator	Funding Agency	Duration (in Years)	Amount (in Lakhs)	Time span
Search of potent inhibitors against target from L donovani (Visceral Leishmaniasis) using systems biology, virtual screening and molecular dynamics	Prof. Vibin Ramakrishnan, IIT, Ghy	Department of Biotechnology, Govt. of India	2.5	15	Apr 2019 - Jul 2021
Biophysical Characterization of adenylosuccinate lyase‐ a potential drug target from Leishmania donovani‐a computational and molecular approach	Dr. Anju Pappachan, CUG, Gujrat	Department of Biotechnology, Govt. of India	3.5	70	Feb 2017 - Aug 2020
Nanoparticle based approach to enhance the AMP efficacy against AMP resistant bacteria	Dr. Suman Jha, NIT, Rourkela	Department of Biotechnology, Govt. of India	3.5	38	Nov 2016 - Apr 2020
In-Silico design and evaluation of sequences for γD crystallin protein	Prof. Saraswathi Vishveshwara, IISc, Bangalore	Department of Biotechnology, Govt. of India	3.5	50	Jan 2013 - June 2016

Research Publications (Recent)

Authors	Paper Title	Name of the Journal	Year	Vol: page no
Zaved Hazarika and Anupam Nath Jha	Structural and functional premise of transport protein transthyretin in the sight of silver and zinc oxide nanoparticles through atomistic simulations	Inorganica Chimica Acta	2024	563: 121923
Kakali Baruah, Ajit Kumar Singh, Kalpana Kumari, Dasuk Lyngdoh Nongbri, Anupam Nath Jha and Atanu Singha Roy	Interactions of Turmeric- and Curcumin-Functionalized Gold Nanoparticles with Human Serum Albumin: Exploration of Protein Corona Formation, Binding, Thermodynamics, and Antifibrillation Studies	Langmuir	2023	40: 1381–1398
Sana Quraishi, Debanjan Saha, Kalpana Kumari, Anupam Nath Jha and Atanu Singha Roy	Non-covalent binding interaction of bioactive coumarin esculetin with calf thymus DNA and yeast transfer RNA: A detailed investigation to decipher the binding affinities, binding location, interacting forces and structural alterations at a molecular level	International Journal of Biological Macromolecules	2024	257: 128568

Research Publications (Till 2023):

Authors	Paper Title	Name of the Journal	Year	Vol: page no
Debanjan Saha, Nayan Jyoti Borah and Anupam Nath Jha	Molecular scaffold recognition of drug molecules against essential genes of Leishmania donovani using biocomputing approach	South African Journal of Botany	2023	162: 52-63
Priya Kumari, Afrin Mamud and Anupam Nath Jha	Review on the Drug Intolerance and Vaccine Development for the Leishmaniasis	Current Drug Targets	2023	24: 1023-1031
Sona Lyndem, Upasana Hazarika, Anindita Bhatta, Vivek Prakash, Anupam Nath Jha and Atanu Singha Roy	In-vitro Interactions of Esculin and Esculetin with Bovine Hemoglobin Alter its Structure and Inhibit Aggregation: Insights from Spectroscopic and Computational Studies	New Journal of Chemistry	2023	47: 14447
Anupam Nath Jha	Editorial: Computational approaches to build therapeutic paradigms targeting genes, proteins and pathways against neglected tropical diseases (NTDs)	Frontiers in Genetics	2023	14: 1183034
Indu Kumari, Dinesh Lakhanpal, Sandeep Swargam and Anupam Nath Jha	Leishmaniasis: Omics approaches to understand its biology from molecule to cell level	Current Protein & Peptide Science	2023	24: 229 - 239
Debanjan Saha and Anupam Nath Jha	Computational multi-target approach to target essential enzymes of Leishmania donovani using comparative molecular dynamic simulations and MMPBSA analysis	Phytochemical Analysis	2023	34: 842 - 854
Saynaz A Choudhary, Debarun Patra, Archana Sinha, Sayani Mazumder, Rajat Pant, Raju Chouhan, Anupam Nath Jha, Biswamohan Prusty, Debasis Manna, Sajal K Das, Kulbhushan Tikoo, Durba Pal and Suman Dasgupta	A small molecule potent IRAK4 inhibitor abrogates lipopolysaccharide-induced macrophage inflammation in-vitro and in-vivo	European Journal of Pharmacology	2023	944: 175593
Sona Lyndem, Upasana Hazarika, P Athul, Anindita Bhatta, Vivek Prakash, Anupam Nath Jha and Atanu Singha Roy	A comprehensive in vitro exploration into the interaction mechanism of coumarin derivatives with bovine hemoglobin: Spectroscopic and computational methods	Journal of Photochemistry and Photobiology A: Chemistry	2022	436: 114425
Omkar Indari, Ajit Kumar Singh, Deeksha Tiwari, Hem Chandra Jha and Anupam Nath Jha	Deciphering antiviral efficacy of malaria box compounds against malaria exacerbating viral pathogens-Epstein Barr Virus and SARS-CoV-2, an in silico study	Medicine in Drug Discovery	2022	16: 100146
Sharat Sarmah, Upasana Hazarika, Sony Moni Das, Sana Quraishi, Anindita Bhatta, Vinay Kumar Belwal, Anupam Nath Jha and Atanu Singha Roy	Deciphering the interactions of phytochemicals with ovalbumin, the major food allergen from egg-white: Spectroscopic and computational studies	Luminescence	2022	37: 2105- 2122
Muzamil Ahmad Rather, Debanjan Saha, Shuvam Bhuyan, Anupam Nath Jha and Manabendra Mandal	Quorum Quenching: A Drug Discovery Approach Against Pseudomonas aeruginosa	Microbiological Research	2022	264: 127173
Zaved Hazarika, Surovi Saikia and Anupam Nath Jha	Interaction of Nanomaterials with Protein-Peptide	Current Protein & Peptide Science	2022	23: 548 - 562
Ankita Khataniar, Upasana Pathak, Sanchaita Rajkhowa and Anupam Nath Jha	A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19	COVID	2022	2: 148-167
Vandana Vinayak, Mohd Jahir Khan, Anupam Nath Jha and Harish	Photosystem I P700 Chlorophyll a Apoprotein A1 as PCR Marker to Identify Diatoms and their Associated Lineage	Journal of Eukaryotic Microbiology	2021	68: e12866
Shweta Jakhmola, Zaved Hazarika Anupam Nath Jha and Hem Chandra Jha	In silico analysis of antiviral phytochemicals efficacy against Epstein–Barr virus glycoprotein H	Journal of Biomolecular Structure and Dynamics	2021	11:179
Nikita Bora and Anupam Nath Jha	In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis – A Kinetic Modeling Approach	Frontiers in Genetics	2020	11:179
Sourav Das, Zaved Hazarika, Sharat Sarmah, Kakali Baruah, Mostofa Ataur Rohman, Debojit Paul, Anupam Nath Jha and Atanu Singha Roy	Exploring the interaction of bioactive kaempferol with serum albumin, lysozyme and hemoglobin: A biophysical investigation using multi-spectroscopic, docking and molecular dynamics simulation studies	Journal of Photochemistry and Photobiology B Biology	2020	205:111825
Sourav Das, Sharat Sarmah, Zaved Hazarika, Mostofa Ataur Rohman, Pallavi Sarkhel, Anupam Nath Jha and Atanu Singha Roy	Targeting the heme protein hemoglobin by (−)-epigallocatechin gallate and the study of polyphenol–protein association using multi-spectroscopic and computational methods	Physical Chemistry Chemical Physics	2020	22:2212-2228
Zaved Hazarika and Anupam Nath Jha	Computational Analysis of the Silver Nanoparticle–Human Serum Albumin Complex	ACS Omega	2020	5:170-178
Saynaz A Choudhary, Nikita Bora, Dipanjan Banerjee, Leena Arora, Anindhya Sundar Das, Rakesh Yadav, Karl-Norbert Klotz, Durba Pal, Anupam Nath Jha and Suman Dasgupta	A novel small molecule A2A receptor agonist, indirubin-3'-monoxime, alleviates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocyte	Biochemical Journal	2019	476:2371-2391
Nikita Bora and Anupam Nath Jha	An integrative approach using systems biology, mutational analysis with molecular dynamics simulation to challenge the functionality of a target protein	Chemical Biology & Drug Design	2019	93:1050-1060
Sapna M. Borah and Anupam Nath Jha	Identification and analysis of structurally critical fragments in HopS2	BMC Bioinformatics	2019	19(Suppl 13):552
Parth S Nayak, Sapna M Borah, Himanshu Gogoi, Shreyasi Asthana, Rakesh Bhatnagar, Anupam Nath Jha and Suman Jha	Lactoferrin adsorption onto silver nanoparticle interface: implications of corona on protein conformation, nanoparticle cytotoxicity and the formulation adjuvanticity	Chemical Engineering Journal	2019	361:470-484
Shreyasi Asthana, Zaved Hazarika, Parth S Nayak, Jyoti Roy, Anupam Nath Jha, Bibekanand Mallick and Suman Jha	Insulin adsorption onto zinc oxide nanoparticle mediates conformational rearrangement into amyloid-like structure with enhanced cytotoxic propensity	BBA - General Subjects	2019	1863:153-166
Sourav Das, Nikita Bora, Mostofa Ataur Rohman, Raju Sharma, Anupam Nath Jha and Atanu Singha Roy.	Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: An overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies.	Physical Chemistry Chemical Physics	2018	20: 21668-21684
Sourav Das, Portia Khanikar, Zaved Hazarika, Mostofa Ataur Rohman, Antara Uzir, Anupam Nath Jha and Atanu Singha Roy	Deciphering the Interaction of 5,7‐Dihydroxyflavone with Hen-Egg-White Lysozyme through Multispectroscopic and Molecular Dynamics Simulation Approaches	Chemistry Select	2018	3:4911-4922
Sanchaita Rajkhowa, Sapna M Borah, Anupam Nath Jha and Ramesh Ch. Deka	Design of Plasmodium falciparum PI(4)KIIIβ Molecular Dynamics and Molecular Docking Methods	Chemistry Select	2017	2:1783-1892
M Arakha, Sapna M Borah, M Saleem, Anupam Nath Jha, Suman Jha	Interfacial assembly at silver nanoparticle enhances the antibacterial efficacy of nisin	Free Radical Biology and Medicine	2016	101: 434-445
PK Borah, S Chakraborty, Anupam Nath Jha, S Rajkhowa, RK Duary	In silico approaches and proportional odds model towards identifying selective ADAM17 inhibitors from anti-inflammatory natural molecules	Journal of Molecular Graphics and Modelling	2016	70: 129-139
Sanchaita Rajkhowa, Anupam Nath Jha and Ramesh Ch. Deka	Anti-tubercular drug development: computational strategies to identify potential compounds	Journal of Molecular Graphics and Modelling	2015	62: 56-68
Nabanita Saikia, Anupam Nath Jha and Ramesh Ch. Deka	Molecular dynamics study on graphene-mediated pyrazinamide drug delivery onto the pncA protein	RSC Advances	2014	4: 24944-24954
Nabanita Saikia, Anupam Nath Jha and Ramesh Ch. Deka	Dynamics of Fullerene-Mediated Heat-Driven Release of Drug Molecules from Carbon Nanotubes	The Journal of Physical Chemistry Letters	2013	4: 4126−4132
Nabanita Saikia, Anupam Nath Jha and Ramesh Ch. Deka	Interaction of pyrazinamide drug functionalized carbon and boron nitride nanotubes with pncA protein: A molecular dynamics and density functional approach	RSC Advances	2013	3: 15102-15107
Anupam Nath Jha, Vishveshwara S. and Banavar JR.	Amino acid interaction preferences in helical membrane proteins	Protein Engineering Design and Selection	2011	24(8): 579-588
Anupam Nath Jha, Vishveshwara S. and Banavar JR.	Amino acid interaction preferences in proteins	Protein Science	2010	19(3): 603-616
Anupam Nath Jha, Ananthasuresh GK, Vishveshwara S.	A search for energy minimized sequences of proteins	PLoS One	2009	4(8): e66848
Anupam Nath Jha, Vishveshwara S.	Inter-helical interactions in membrane proteins: analysis based on the local backbone geometry and the side chain interactions	Journal of Biomolecular Structure and Dynamics	2009	26(6): 719-729
Anupam Nath Jha, Ananthasuresh GK, Vishveshwara S.	Protein sequence design based on the topology of the native state structure	Journal of Theoretical Biology	2007	248(1): 81-90
Luthra A, Anupam Nath Jha, Ananthasuresh GK, Vishveshwara S.	A method for computing the inter-residue interaction potentials for reduced amino acid alphabet	Journal of Biosciences	2007	32(5): 883-889

Conference Proceedings:

Anupam Nath Jha, Ananthasuresh, GK., and Vishveshwara, S. A Search for Energy Minimized Sequences of Proteins. Biophysical Journal 2010 Jan; 98(3, Supplement 1): 575a.
Sapna Mayuri Borah, Anupam Nath Jha. Identification of important structural regions and validation in HopS2 effector protein. Journal of PROTEINS AND PROTEOMICS 2017 8 (3).
Nikita Bora, Anupam Nath Jha. 2D-QSAR and soft docking: an integrative approach for screening of phytochemicals. Journal of PROTEINS AND PROTEOMICS 2017 8 (3).
Nikita Bora, Anupam Nath Jha. Tannic acid: an efficient quorum sensing inhibiter.International Conference on Systems and Processes in Physics, Chemistry and Biology (ICSPPCB-2018), ISBN: 978-81-934859-0-3
Zaved Hazarika, Anupam Nath Jha. A Comparative Evaluation of Docking Programs using Influenza Endonuclease as Target Protein. International Conference on Computational Performance Evaluation (ComPE), 2020; 321-326.
Debanjan Saha, Anupam Nath Jha. Multi-target approach on Leishmania donovani and finding out potent inhibitors for essential enzymes. XXXVIII Symposium of Bioinformatics and Computer-Aided Drug Discovery, 2022; 92.

Book Chapters:

Zaved Hazarika, Upasana Hazarika, Babli Sharma, Anupam Nath Jha. "Importance and Potential Applications of Nanobiotechnology and Systems Biology for Livestock Science" in the edited book entitled Systems Biology, Bioinformatics and Livestock Science (ISBN: 978-981-5165-62-3)

Sibasree Hojaisa, Anupam Nath Jha. "Databases and Tools for Microbial Genome and Human Microbiome Studies" in the edited book entitled Industrial Microbiology and Biotechnology (ISBN: 978-981-99-2815-6)

Debanjan Saha, Ankita Khataniar, Ajit Kumar Singh, Anupam Nath Jha. "Review of methods for encapsulation of nutraceutical compounds" in the edited book entitled Nutraceuticals Sources, Processing Methods, Properties, and Applications (ISBN: 978-0-443-19193-0)

Subhomoi Borkotoky, Amit Joshi, Vikas Kaushik, Anupam Nath Jha. "Machine Learning and Artificial Intelligence in Therapeutics and Drug Development Life Cycle" in the edited book entitled Drug Development Life Cycle (ISBN: 978-1-83968-483-8)

Abhichandan Das, Upasana Pathak, Sanchaita Rajkhowa, Anupam Nath Jha. "Plasmodium falciparum: Experimental and Theoretical Approaches in Last 20 Years" in the edited book entitled Current Topics and Emerging Issues in Malaria Elimination (ISBN: 978-1-83968-483-8)

Sanchaita Rajkhowa, Zaved Hazarika, Anupam Nath Jha. "Systems biology and bioinformatics approaches in leishmaniasis" in the edited book entitled Applications of Nanobiotechnology for Neglected Tropical Diseases (ISBN: 978-0-12-821100-7)

Zaved Hazarika, Sanchaita Rajkhowa, Anupam Nath Jha. "Role of Force Fields in Protein Function Prediction" in the edited book entitled Homology Molecular Modeling - Perspectives and Applications (ISBN: 978-1-83962-806-1)

Sanchaita Rajkhowa, Anupam Nath Jha. "Molecular Dynamics Simulations: A Tool to Investigate the Interactions between Biomolecules and Nanoparticles" in the edited book entitled An Introduction to Molecular Dynamics (ISBN: 978-1-53616-054-3)