Research Interest Publications Research Projects Research Group Important Links_
Educational Qualifications
Ph.D in Immunology
from Post Graduate Institute of Medical Education and Research, Chandigarh,
India
M.Sc ( Hons.) in Microbiology from Panjab University, Panjab,
India
Professional Experience
·
2013 -
present: Professor, Department of Molecular Biology and Biotechnology, Tezpur
University, Assam, India
·
2007 -
2013: Associate Professor, Department of Molecular Biology and Biotechnology,
Tezpur University, Assam, India
·
2004 -
2007- Reader, Department of Molecular Biology and Biotechnology, Tezpur
University, Assam, India
·
2002 -
2004: Lecturer, Department of Molecular Biology and Biotechnology, Tezpur
University, Assam, India
·
2001 -
2002 : Scientific Officer, Medecins Sans Frontiers (MSF), Assam, India
·
1997 -
2002: Guest Faculty, Department of Biotechnology, Gauhati
University, Assam, India.
Broadly
our laboratory is engaged in research in the areas of immunology and immunogenetics. Our
focus is in understanding
the heterogeneity and evolution of immune response in context of human genetics
and migration to identify susceptibility/ risk determinants and possible
targets of immunotherapeutic interventions in various ethnic
populations. Our lab is currently engaged in understanding the regulation
of cytokine networks in malaria, diversity and activation of NK cells, TLR
polymorphisms and inflammasome activation in squamous cell cancers of Head
and Neck region. In S.L.E we are investigating HLA allele associations and
activation of sub populations of immune cells.
Teaching Experience
Undergraduate Teaching
Immunology
Microbiology
Post Graduate Teaching
Immunology
Immunotechnology
Evolutionary
Immunogenetics
Doctoral Studies
Evolutionary
Immunogenetics
Developmental
Biology
Society Membership
§ Life member of Indian Immunology Society (IIS)
Recognitions (Selected)
§ Member of Task Force on Human Resource Development,
Department of Biotechnology, Govt. of India; 2014-2017
§ Vice President (East) for Indian Immunology Society
from 2018-2020
§ Vice President (East) for Indian Immunology Society
from 2014-2016
§ Member of Scientific Review Committee ( TMC&H, NECHRI, LGBRIMH etc )
§ Chairperson, Internal Complaint Committee, Tezpur
University, 2014-present
§ Member, Course Advisory Committee, Tezpur University
Research Supervision
·
Doctoral
Studies- Completed and Ongoing: 13
·
M.Sc.
Dissertation: 40
1.
Sarmah, N., Baruah, M.N., Baruah,
S., Immune modulation in HLA-G expressing Head and Neck
Squamous Cell Carcinoma in relation to Human Papilloma Virus positivity: a study
from North-East India. Frontiers in Oncology, Section- Head & Neck Cancer,
doi: 10.3389/fonc.2019.00058, 2019, (Impact factor-
4.4)
2.
Mahanta,
A., Ganguli, P., Barah, P., Sarkar, R.R., Sarmah, N., Phukan, S., Bora., M., Baruah, S., Integrative
Approaches to Understand the Mastery in Manipulation of Host Cytokine Networks
by Protozoan Parasites with Emphasis on Plasmodium and Leishmania Species.
Frontiers in Immunology, 9:296. doi:
10.3389/fimmu.2018.00296 9, 2018.
(Impact factor- 5.5).
3. Mahanta, A., Baruah, S., Lower expression of GATA3 and T-bet correlates with downregulated IL-10 in severe falciparum malaria. Clinical and Translational Immunology, doi: 10.1038/cti.2015.30, 4(11), e49, 2015. (Impact factor- 3.5).
4.
Dutta,
A., Banerjee, A., Saikia, N., Phookan, J., Narayan,
M., Baruah, S.,
Negative regulation of natural killer cell in tumor tissue and peripheral blood
of oral squamous cell carcinoma, Cytokine, 76(2), 123-130, 2015 (Impact factor-
3.5).
5. Mahanta, A., Kar, S. K., Kakati, S., Baruah, S., Heightened inflammation in severe malaria is associated with decreased IL-10 expression levels and neutrophils, Innate Immunity 21(5),546-552,2015 . (Impact factor- 2.3).
6. Mahanta, A., Kakati, S., Baruah, S., The association of IL8-251 T/A polymorphism with complicated malaria in Karbi Anglong district of Assam, Cytokine, 65:210-216 , 2015 (Impact factor – 3.5).
7. Dutta, A., Saikia, N., Phookan, J., Baruah, M.N., Baruah, S., Association of Killer cell immunoglobulin-like receptor gene 2DL1 and its HLA-C2 ligand with family history of cancer in oral squamous cell Carcinoma, Immunogenetics, 66(7-8), 439-448, 2015 (Impact factor – 2.0).
8. Dutta, A., Lourembam, S.D., Pradhan, S., Baruah, S., KIR diversity in three ethnic populations of Assam state, Northeast India, 2013,Tissue Antigens, Volume 82, Issue 1, pages 48–52, 2013 (Impact factor – 2.5).
9.
Lourembam, S.D., Sawian, C.E., Baruah,
S., Dysregulation of cytokines expression in complicated falciparum malaria
with increased TGF-beta and IFN-gamma and decreased IL-2 and IL-12,2013
Cytokine,64(2):503-8, 2013 (Impact factor -3.5).
10. Khanppnavar, B., Baruah, S., Ray, S.K., TALE: an
emerging tool for genome editing and genetic engineering, Current Science, 104
(5), 576-578, 2013. (Impact factor –
0.4)
11. Sawian, C.E., Lourembam, S.D., Banerjee, A., Baruah, S.,
Polymorphisms and expression of TLR4 and 9 with malaria in two ethnic groups of
Assam, Northeast India, Innate Immunity,19 (2),174-183, 2012. (Impact factor –
2.3)
12. Lourembam, S.D., Baruah, S., Antibody response to
allelic variants of 19 kDa fragment of MSP-1: Recognition of a
variant and protection associated with ethnicity in Assam, India, Vaccine,
30 (4), 767–773, 2012. (Impact factor – 3.2)
13. Lourembam, S.D., Sawian, C.E., Baruah, S.,
Differential
association of KIR gene loci to risk of malaria in ethnic groups of Assam,
Northeast India , Infection, Genetics and
Evolution 11 (8), 1921-1928,
2011. (Impact factor- 2.5)
14. Konwarh,
R., Karak, N.,
Sawian, C.E.,
Baruah, S., Mandal,
M., Effect of sonication and aging on the templating
attribute of starch for “green” silver nanoparticles and their interactions at
bio-interface, Carbohydrate Polymers,83 (3), 1245-1252,2011. (Impact factor- 5.1)
15. Kumar,V.B., Sawian, C.E., Mohanta, D., Baruah, S., Islam, N.S., Physical and
biophysical characteristics of nanoscale tungsten oxide particles and their
interaction with human genomic DNA, Journal of Nanoscience and
Nanotechnology,11 (6), 4659-4666, 2011. (Impact factor- 1.3)
16. Baruah, S., Lourembam, S.D., Sawian, C.E., Baruah, I., Goswami,
D., Temporal and spatial variation in MSP1 clonal composition of Plasmodium
falciparum in districts of Assam, Northeast India, Infection, Genetics and
Evolution, 9 (5), 853-859, 2009. (Impact
factor- 2.5)
17. Kalita, D., Sarmah, S., Das, S.P., Baishya,
D., Patowary, A., Baruah, S., Synthesis, characterization, reactivity and
antibacterial activity of new peroxovanadium(V)
complexes anchored to soluble polymers, Reactive and Functional Polymers, Volume 68, Issue
4, Pages 876-890, 2008. (Impact
factor- 2.9)
18. Campbell, P., Baruah, S., Narain, K., Rogers, C.C., A
randomized trial comparing the efficacy of four treatment regimens for
uncomplicated falciparum malaria in Assam state, India, Transactions of the Royal
Society of Tropical Medicine and Hygiene 100 (2), 108-18, 2006. (Impact factor- 2.8)
|
Serial
No. |
Project
Title |
Funding
Body |
Status |
|
1 |
Diagnosis and Immunopathogenesis of Dengue Virus Infections;
a longitudinal investigation into genotype diversity, diagnosis and immune
response to dengue infections in Assam, Northeast India |
DRDO |
Ongoing |
|
2 |
Polymorphism
of Toll like and Nod like receptors and their role in inflammasome activation
in Head and Neck Squamous Cell Carcinoma |
ICMR |
Ongoing |
|
3 |
Systemic
Lupus Erythematosus (SLE) - An investigation into diagnostics and disease
pathogenesis |
DBT |
Completed |
|
4 |
KIR
haplotypic variation and activation of natural killer cells in
Cancer |
ICMR |
Completed |
|
5 |
Understanding
the molecular interactions between NK receptor diversity and activation with
diverse malignancy in HNSCC prevalent in the population of Assam |
DBT |
Completed |
|
6 |
Longitudinal
analysis of changes in cytokine profile of malarial patients at different
stages of treatment and disease resolution: Understanding molecular basis of cure and malarial pathology. |
DBT |
Completed |
|
7 |
Genetic
diversity and molecular epidemiology of Plasmodium falciparum infections in
districts of Assam |
DRL,
DRDO |
Completed |
|
8 |
Molecular
Immuno epidemiology of Plasmodium falciparum infections in border districts
of Assam |
DRL,
DRDO |
Completed |
|
9 |
Synthesis
and studies on polymer immobilized peroxo complexes of some transition elements
from Department of Science and Technology. Collaborative project with Prof.
N. Islam, Chemical Sciences, Tezpur University |
DST |
Completed |
|
10 |
Application
of traditional communication methods to influence health awareness and health
seeking behaviour |
Panos
Southeast Asia |
Completed |
|
|
Neelanjana Sarmah Ph.D. Research Scholar Research
Area: Investigation of tumor microenvironment of Head & Neck
Squamous Cell Carcinoma (HNSCC) in relation to immune cell suppression and
association of HPV with the disease Email: neela@tezu.ernet.in |
|
|
Saurav Phukan Ph.D. Research Scholar Research
Area: Understanding Immune Suppression of Natural Killer Cells in Head
and Neck Squamous Cell Carcinoma Email: phukans@tezu.ernet.in |
|
|
Mayuri Bora Ph.D. Research Scholar Research
Area: Interaction of autoantibodies and KIR-HLA genotypes in relation
to pregnancy outcome in populations of Assam. Email: bmayuri@tezu.ernet.in |
|
|
Dr. Pawan Kumar Ph.D. Research Scholar Research
Area:
Assessment and Comparison of Inflammatory Cytokines and Gene Polymorphism in
Chronic and Aggressive Periodontitis. Email: drpkperio@gmail.com |
|
|
Arunav Saikia Project Assistant Research
Area : Diagnosis and Immunopathogenesis of Dengue Virus Infections; a
longitudinal investigation into genotype diversity, diagnosis and immune
response to dengue infections in Assam, Northeast India Email: arnvs16@tezu.ernet.in |
|
|
Gurumayum Chourajit Sharma Ph.D. Research Scholar Research
Area : Autoimmunity Email: guru_18@tezu.ermet.in |
|
|
Bhaswatee Das Ph.D. Research Scholar Research
Area : Computational Immunology Email:
bhasdas@tezu.ernet.in
|
|
|
Dalal Hemaya Ph.D. Research Scholar Research
Area : Immunometabolism Email:
dalalmb@tezu.ernet.in |
Lab Alumni
|
|
Dr. Clara Ermine Sawian Assistant
Professor, St. Anthony’s College, Shillong, Meghalaya |
|
|
|
Dr. Sonia Devi Lourambam Assistant
Professor, Bhaskaracharya College of Applied
Sciences, Dwarka |
|
|
|
Dr. Anupam Dutta Post Doc. Fellow, INSTEM, NCBS,
Bangalore |
|
|
|
Dr. Anusree Mahanta Post Doc. Fellow, INSTEM, NCBS,
Bangalore |
|
|
|
Mr. Arunabha Banerjee Professional
Blogger and PGT, KV, Doomdooma, Assam |
|
|
|
Ms. Indrani Kalita Former Lab Technician, Systemic
Lupus Erythematosus (SLE) - An investigation into diagnostics and disease
pathogenesis |
|
|
|
Ms. Sairem BabyThoithoi CSIR- National Botanical Research Institute, Lucknow, Uttar Pradesh
|
|
|
|
Mr. Akash Protim Gogoi Former Ph.D. Research Scholar
|
|
|
Ms. Debashree Talukdar Former Ph.D. Research Scholar
|
|
|
Dr. Johirul Islam
Research Associate, Defence Research Laboratory, Solmara, Tezpur
|
2017-2019 Batch
Sushmita H Singha
Vatsala Pokhrel
2016-2018
Batch
Gurumayum Chourajit Sharma
Himadree Das
Suman
Pakhira
2015-2017
Batch
Anindita Gohain Baruah
Daradi Patar
Manikrao Thakare
2014-2016
Batch
Namrata Borah
Muktashree Saha
Salique Hassan Shaham
2013-2015 Batch
Bhaswatee Das
Ankur Chowdhary
Sohenii Bhattacharjee
Anjum Dihingia
2012-2014
Batch
Ankit
Gupta
Ranbala Ranu
2011-2013
Batch
Debashree Talukdar
Basavraj Khanapnavar
2010-2012 Batch
Rowel
Rongphar
Mayurakhi Borpujari
Niraj Kumar Sonkar
2009-2011 Batch
Ankita Borah
Rituparna Deka
2008-2010
Batch
Arunabha
Bannerjee
Beauty Borah
2007-2009
Batch
Srikant Pradhan
Muhsin Mushtaque
2006-2008
Batch
Saujanya Acharya
Aditi
Neog
Alka Kumari
2005-2007
Batch
Joubert B Kharlyngdoh
Angom Ramcharan
Nabamita Roy
2004-2006
Batch
Ashok
Patowary
Diganta Baishya Pariksha
Nilakshi Baruah
2003-2005
Batch
Sonia
Lourembam
Clara Ermine Sawian
The
database provides a centralised repository for human KIR sequences. Killer-cell
Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at
the allelic and haplotypic level. KIRs are members of the immunoglobulin
superfamily (IgSF) formerly called Killer-cell Inhibitory Receptors. They are
composed of two or three Ig-domains, a transmembrane region and cytoplasmic
tail which can in turn be short (activatory) or long (inhibitory). The
Leukocyte Receptor Complex (LRC) which encodes KIR genes has been shown to be
polymorphic, polygenic and complex like the MHC
The
IMGT/HLA Database provides a specialist database for sequences of the human
major histocompatibility complex (HLA) and includes the official sequences for
the WHO Nomenclature Committee for Factors of the HLA System. The IMGT/HLA
Database is part of the international ImMunoGeneTics project
3. The Allele Frequency Net Database
This
site provides one central source, freely available to all, for the storage of
allele frequencies from different polymorphic areas in the HUMAN genome.
4. National Centre for Biotechnology Information
The National Centre22 for Biotechnology Information advances science and health by providing access to biomedical and genomic information
Indian
Immunology Society was formed to facilitate the exchange of
ideas & information amongst scientists working in different research
areas of Immunology
Last Updated on 10th May
2019