Cellular, Molecular and Environmental Biotechnology Laboratory   RUPAK MUKHOPADHYAY Assistant Professor Department of Molecular Biology and Biotechnology Tezpur University, Assam 784 028 Contact: +91-3712-275417 Email: mrupak(AT)tezu.ernet.in; mrupak(AT)gmail.com

 

Academic Qualifications

        Ph. D. (Microbial Biotechnology) - Indian Association for the Cultivation of Science, Kolkata, India (Degree from Jadavpur University), 2003

        M. Sc. (Biochemistry) - University of Calcutta, India, 1997

        B. Sc. (Chemistry)- University of Calcutta, India, 1995

Career Profile

       Assistant Professor, Department of Molecular Biology and Biotechnology, Tezpur University (Nov 2011-till date)

        Section Head, Transcriptomics and Immunohistochemistry, Thrombosis Research Institute, Bangalore, India (Mar 2009-Oct 2011)

        Research Associate, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA (Dec 2008-Mar 2009)

        Postdoctoral Fellow, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA (Oct 2002-Nov 2008)

Research Interests

        Inflammation and Cardiovascular disease; Environmental Biotechnology; Food Microbiology

Research Projects

    1. Unit of Excellence (U-Excel) project 2014-2017, Department of Biotechnology, Govt. of India (PI; Funding 152.07 Lakhs)

    2. Twining program 2014-2017, Department of Biotechnology, Govt. of India (PI; Total Funding 77.41 Lakhs, TU share 48.60 Lakhs)

    3. SERB project 2015-18, Department of Science and Technology, Govt. of India (PI; Total Funding 50.18 Lakhs, TU share 25.94 Lakhs)

 

Honors/Awards
 

        Robert F. Tarazi Fellowship Award for outstanding contribution in cardiovascular research, Cleveland Clinic, May 2008, Cleveland, USA.

        Outstanding Oral Presentation Award at Rustbelt RNA Meeting, Oct 2006, Mt. Sterling, OH, USA.

        Best Poster award at the Lerner Research Institute Staff Retreat, Sep 2006, Geneva, OH, USA.

        Agouron Foundation Travel Award for oral presentation in 7^th International Conference on Ribosome Synthesis, Aug 2006, Warrenton, USA.

Courses teaching

        Genetic Engineering (BT 451 and BI 403)

        Genetic Engineering Laboratory (BT 419)

        Molecular Biology (BT 403 and BI 321)

        Molecular Biology Laboratory (BT 408)

        Animal Biotechnology (BI 402)

        Research Methodology (BT 710)

Group Members

	Rupak Mukhopadhyay
	Dr Linee Goswami
	Anandita Basu (Ph. D. student) Research area: Mechanism of Anti-inflammatory activity of polyphenols
	Munmi Majumder (Ph. D. student) Research area: Anticancer properties of natural products
	Anindhya S. Das (Ph. D. student) Research area: Inflammation and ribosomal proteins
	Manoj Sharma (Ph. D. student.) Research area: TBD

 

Current project student

    1. Subhojit Bakshi (M. Sc. 2017-18 batch)

Lab Alumni 

Ph. D. student

1.    Manash Deep Dey (2013-2017)

Project students

    1. Bhanupriya Pegu (Project student Int M. Sc. 2012-17 batch)

    2. Masihuzzaman Ansari (Project student M. Sc. 2015-17 batch)

    3. Jyoti Pd. Deka (Project studentM. Sc. 2015-17 batch)

    4. Sharmila Talukdar (Project student M.Sc. 2014-16 batch, currently pusuing Ph.D at)

    5. Minhaz Ahmed (Project student Int. M.Sc. 2011-16 batch, currently pursuing Ph.D. at Tezpur University)

    6. Rimpi Saikia (Project student Int. M.Sc. 2011-16 batch; currently project student at ACTREC, Mumbai)

    7. Sujay Pal (Project student M.Sc. 2013-15 batch, currently pursuing Ph.D. in CSIR-IICB, Kolkata)

    8. Ranjana Singh (Project student M.Sc. 2013-15 batch)

    9. Debashree Tagore (Project student M. Sc. 2012-14 batch, currently pursuing Ph.D. at NIBMG, West Bengal)

    10. Nilanjan Som (Project student M. Sc. 2012-14 batch, currently pursuing Ph.D. at CCMB, Hyderabad)

    11. Anand Bhushan (Project student M. Sc. 2011-13 batch, currently pursuing Ph.D. at  NIBMG, West Bengal)

    12. Ruchi Shukla (Project student M. Sc. 2011-13 batch)

    13. Syed Wasim Parvez (Ph. D. student, 2013-14, currently pursuing Ph.D. at NIT, Durgapur)

    14. Deepjyoti Kumar Das (J. R. F. 2014-15, currently pursuing Ph.D. at IMTECH, Chandigarh)

 

Publications 

Cell and molecular biology

 

1.    STAT3 and NF-kB are Common Targets for Kaempferol-mediated Attenuation of COX-2 Expression in IL-6-induced Macrophages and Carrageenan-induced Mouse Paw Edema- Anandita Basu, Anindhya S. Das, Manoj Sharma, Manash P. Pathak, Pronobesh Chattopadhyay, Kaushik Biswas and Rupak Mukhopadhyay^*, Bichem. Biophys Rep, 12, 54-61, 2017.

 

2.    Anti-atherogenic Role of Chrysin, Quercetin and Luteolin- Anandita Basu, Anindhya Sundar Das, Munmi Majumder and Rupak Mukhopadhyay*, J. Cardiovasc. Pharmacol., 68, 89-96, 2016.

 

3.    Understanding the progression of atherosclerosis through gene profiling and co-expression network analysis in Apob^tm2sgyldlr^tm1her double knockout mice- Vrushali Deshpande, Ankit Sharma, Rupak Mukhopadhyay, Lakshmi Narasimha Rao Thota, Madankumar Ghatge, Rajani Kanth Vangala, Vijay V. Kakkar and Lakshmi Mundkur, Genomics, 107, 239-247, 2016.

 

4.    Protein arginylation regulates cellular stress response by stabilizing hsp70 and hsp40 transcripts- Kamalakshi Deka, Archana Singh, Surajit Chakraborty, Rupak Mukhopadhyay and Sougata Saha, Cell Death Discovery, 2, e16074, 2016.

 

5.    Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity- Maitreyee Sharma, Janaki Krishnamurthy Iyer, Norrapat Shih, Munmi Majumder, Venkata Satish Kumar Mattaparthi, Rupak Mukhopadhyay and Robin Doley, PLoS One, 11(4): e0153770, 2016.

 

6.    Hypercholesterolemia Induced Immune Response and Inflammation on Progression of Atherosclerosis in Apobtm2SgyLdlrtm1Her/J Mice - Lakshmi Narasimha Rao, Thiruvelselvan Ponnusamy, Sheena Philip, Sagar Tarate, Rupak Mukhopadhyay, Vijay V Kakkar and Lakshmi Mundkur. Lipids, 50, 785-797, 2015.

 

7.    Mucosal Tolerance to a Combination of ApoB and HSP60 Peptides Controls Plaque Progression and Stabilizes Vulnerable Plaque in Apob^tm2SgyLdlr^tm1Her/J Mice- Lakshmi Mundkur,# Rupak Mukhopadhyay,# Sonia Samson, Meenakshi Varma, Dnyaneswar Kale, Daxin Chen, Sneha T S, Hemapriya Sivanandan, Vinod Soman, Xinjie Lu, Vijay V Kakkar. PLoS One, 8(3):e58364, 2013. (# equal contribution).

 

8.    Mouse Models of Atherosclerosis: Critical Roles of Lipid Metabolism and Inflammation- Rupak Mukhopadhyay*. J. Appl. Genetics, 54:185-192, 2013.

 

9.    Comparison of Oral tolerance to ApoB and HSP60 Peptides in preventing atherosclerosis lesion formation in Apobtm2SgyLdlrtm1Her/J Mice-Lakshmi Mundkur, Rupak Mukhopadhyay, Vrushali Deshpande, Sonia Samson, Sagar Tarate, Meenakshi Varma, Sneha Shivaprasad, Xinjie Lu, and Vijay V. Kakkar, Journal of Vaccines, Vol 2013, 2013, Article ID 212367, 13 pages.

 

10.  Coding Region Polyadenylation Generates a Truncated tRNA Synthetase that Counters Translational Repression- Peng Yao, Alka A. Potdar, Abul Arif, Partho Sarothi Ray, Rupak Mukhopadhyay, Bellinda Willard, Yichi Xu, Jun Yan, Gerald M. Saidel and Paul L. Fox, Cell, 149, 88-100, 2012.

 

11.  Two-site Phosphorylation of EPRS Coordinates Multimodal Regulation of Noncanonical Translational Control Activity- Abul Arif, Jie Jia, Rupak Mukhopadhyay, Belinda Willard, Michael Kinter and Paul L. Fox, Mol. Cell, 35, 164-180, 2009.

 

12.  The GAIT system: A Gatekeeper of Inflammatory Gene Expression- Rupak Mukhopadhyay, Jie Jia, Abul Arif, Partho S. Ray and Paul L. Fox, Trends Biochem. Sci., 34, 324-331, 2009. (Featured as a cover page article).

 

13.  DAPK-ZIPK-L13a Axis Constitutes a Negative-Feedback Module Regulating Inflammatory Gene Expression - Rupak Mukhopadhyay, Partho S. Ray, Abul Arif, Anna Brady, Michael Kinter and Paul L. Fox, Mol. Cell, 32, 371-382, 2008. (IF= 14.46) [This article was previewed in “Signaling Pathways Open the GAITways to Translational Control”- S. J. Morley and M. Willet, Dev. Cell, 15, 639, 2008 and evaluated by Faculty of 1000].

 

Environmental biotechnology

 

14.  Adsorption of Methylene blue and Rhodamine B by using biochar derived from Pongamia glabra seed cover- Neonjyoti Bordoloi, Manash D. Dey, Rupak Mukhopadhyay and Rupam Kataki, Water Sci. Technol. 2017.

 

15.  Vermiremoval of Methylene Blue using Eisenia fetida: A Potential Strategy for Bioremediation of Synthetic Dye-Containing Effluents- Manash Deep Dey, Subhasish Das, Rupesh Kumar, Robin Doley, Satya Sundar Bhattacharya and Rupak Mukhopadhyay*, Ecol. Engg. 106, 200-208, 2017.

 

16.  Utilization of Two Agrowastes for Adsorption and Removal of Methylene Blue: Kinetics and Isotherm Studies- Manash Deep Dey, Minhaz Ahmed, Ranjana Singh, Ratan Boruah and Rupak Mukhopadhyay*, Water Sci. Technol., 75, 1138-1147, 2017.