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Mechanism of action of snake venom toxins (particular reference to PLA2, three-finger family of toxins, L-amino acid oxidase, snaclec, nerve growth factor and proteases) from Russell’s viper and cobra venom, management of snakebite, pharmacological screening of medicinal plants for snakebite treatment, analysis of venom proteomes, antivenomics. |
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Industrially important microbial enzymes, solid-waste management, bioremediation of petroleum oil hydrocarbons in soil and water, microbial biodesulfurization. |
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Pharmaceutical and diagnostic applications of snake venom toxins and proteins, therapeutic application of bacterial proteins and medicinal plants in the prevention and/or treatment of thrombosis and hyperfibrinogenemia related cardiovascular disorders, diagnostic application of nerve growth factor and α-neurotoxin bounded nanoparticle for endogenous detection of cancer. |
Dr. Yuri Utkin, Ph.D, Professor, National University of Science and Technology “MISIS”, College of New Materials and Nanotechnology, Moscow
Dr. Glenn F. King, Ph.D., Professor, Laboratory Head, Chemistry and Structural Biology Division, Institute of Molecular Bioscience, The University of Queensland, Australia
Dr. Stephen Mackessy, Ph.D., Professor, College of Natural and Health Sciences, University of Northern Colorado, USA
Dr. Dulal Panda, Ph.D., Professor, Department of Biosciences and Bioengineering, IIT Bombay
Dr. Siddhartha Sankar Ghosh, Ph.D., Professor, Department of Biosciences and Bioengineering, IIT Guwahati
Dr. Biplab Bose, Ph.D., Associate Professor, Department of Biosciences and Bioengineering, IIT Guwahati
Dr. Anupam Chatterjee, Ph.D, Professor, Department of Biotechnology and Bioinformatics, NEHU, Shillong
Dr. Subhro Chatterjee, Ph.D, UGC-FRP Associate Professor, Centre for Biotechnology; AU-KBC Research Center, Anna University, Chennai
Dr. Pronobesh Chattopadhyay, Ph.D, Scientist D, Division of Pharmaceutical Technology, DRL, Tezpur
Dr. Choo Hock Tan, MBBS, Ph.D, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala lampur, Malayasia
Dr. Le Van Dong, MD, Ph.D, Department of Toxicology & Radiology, Vietnam Military Medical University, Hanoicity, Vietnam.
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Research Projects Completed: |
|
S. No |
Duration |
Project Title |
Sponsoring agency |
Fund sanctioned (Rupees) |
|
|
1 |
Apr 1999- |
Mar 2000 |
Identification of some local herbs and plants of Assam for antisnake venom activity. |
UGC, New Delhi |
15000.00 |
|
2 |
Oct 1999- |
Mar 2008 |
Isolation, characterization and commercial applications of biosurfactant produced by thermophilic and mesophilic bacteria from the soil samples of Assam, India. |
ONGC-CPBT |
18890000.00 (to the Department) |
|
3 |
Jul 2001- |
Jun 2004 |
Isolation, characterization and biological activities of phospholipase A2 enzyme from Indian monocled cobra (Naja kaouthia) venom. |
UGC, New Delhi |
6120000.00 |
|
4 |
Mar 2005- |
Feb 2008 |
Isolation, biochemical and pharmacological characterization of pro-coagulant and anti-coagulant proteins from Indian Russell’s viper (Daboia russelli) venom. |
UGC, New Delhi |
867000.00 |
|
5 |
Nov 2005- |
Oct 2008 |
Exploration of potential microbes from North-east India for the production of three commercially important enzymes- protease, amylase and cellulose. |
DBT, New Delhi |
894000.00 |
|
6 |
Apr 2009- |
Mar 2014 |
Microbial enzymes, biosurfactant and probiotics (under SAP, DRS-I). |
UGC, New Delhi |
4200000.00 (to the Department) |
|
7 |
Oct 2009- |
Sep 2014 |
Advance Research in Bio-resource Management and Environmental biotechnology |
DBT special project , New Delhi |
29800000.00 (to the Department) |
|
8 |
Sep 2010- |
Aug 2011 |
Demonstration of novelty of protease produced by selected bacteria isolated from North-east India. |
DBT, New Delhi |
714000.00 |
|
9 |
Apr 2011- |
Sep 2014 |
Assessment of thrombolytic potential and anticancer activity of fibrinolytic enzymes purified from Russell’s viper venom and bacteria isolated from NE-India |
DBT, New Delhi |
16000000.00 |
|
10 |
May 2014- |
Apr 2016 |
Proteomics study of aromatic hydrocarbon degradation enzymes of some selected bacterial strain prospecting strategies for environmental bioremediation |
ONGC-CPBT, Tezpur University |
706000.00 |
| 11 |
Dec 2014- |
Nov 2017 |
Application of snake venom toxins labeled with functionalized nanoparticles for detecting endogenous targets in cells and ex vivo tissues with prospects for the development of novel diagnostic and therapy tools |
DBT , new Delhi under Indo-Russia collaborative project |
4560000.00 |
|
12 |
Dec 2014- |
Mar 2018 |
Discovering novel drug formulations from non-toxic, potent anticoagulant components of snake venom for the prevention and/or treatment of cardiovascular disease (CVD). |
DBT, New Delhi under National Bioscience Award for Career Development-2013 |
150000.00 |
|
13 |
Apr 2017 - |
Mar 2018 |
Assessment of purity and contaminating protein(s) in equine polyvalent anti snake venom manufactured by Premium Serum & Vaccines Pvt. Ltd., Pune |
Premium Serum & Vaccines Pvt. Ltd., Pune |
4,05,750.00 |
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Consultancy Projects : (completed) |
|
S. No |
Duration |
Project Title |
Sponsoring agency |
Fund sanctioned (Rupees) |
|
|
1 |
April 2017- |
March 2018 |
Assessment of purity and contaminating protein(s) in equine polyvalent anti snake venom manufactured by premium Serum & Vaccines Pvt. Ltd., Pune |
Premium Serum & Vaccines Pvt. Ltd. |
405000.00 |
|
S. No |
Duration |
Project Title |
Sponsoring agency |
Fund sanctioned (Rupees) |
|
|
1 |
Dec 2014- | June 2018 |
Venomics and antivenomics of Indian Cobra and Russell's viper: implications in drug discovery and quality control of antivenoms |
DBT, New Delhi under Unit of Excellence in NER-2013 scheme | 13220000.00 |
| 2 |
Oct 2016-
|
April 2018 |
Development of a cost-effective, novel antithrombotic anticoagulant herbal drug and standardization of its biomarker assisted quality control |
DBT-BIRAC, New Delhi under BIG scheme
|
4975000.00
|
|
3 |
Feb 2018 |
Jan 2021 |
Studies on epidemiology, hospital management of snakebite, and standardization of laboratory tests for assessment of efficacy and quality control of commercial antivenom manufactured in India and in ASEAN countries |
DST-SERB (Under ASEAN) |
46,43,800.00 |
|
4 |
Apr 2018 |
Mar 2021 |
Development of functionalized nanoparticles-based novel diagnostic kit for the detection of species-specific snake envenomation |
DBT Tata Innovation project |
18,00,000.00 |
|
5 |
Jun 2018 |
Dec 2019 |
Development of snake venom toxins-target specific novel antivenom |
DBT-BIRAC, New Delhi under PACE scheme |
43,10,000.00 |