Research Activities in 2013
We are interested to find out evolutionary selection mechanism on codon usage bias in bacteria. A new method has been developed to find out selection on codon usage bias. Using the method, we have found out that GGU and CGU codons in Gly and Arg family are selected in genome with high G+C%. Our result is also in aggrement with the findings of Wang et al (2011), Wald et al (2012) and Ran & Higgs(2010). So our result is in support of the finding that selection on optimal codons is not essentially in the direction of genome composition unlike the report by Hershberg and Petrov (2009). Using our result , we are able to find out selection mechanism in G+C high bacteria that were previously reported by Sharp et al (2005)to have a low selection using WWY codons.
Finding out novel drugs against bacteria is one of the major challenges in front of bioinformatics research. We are targeting vital metabolism functions in bacteria for this purpose. One of such targets we have taken is anticodon modification enzymes in bacteria. We have visualized the structure of the enzyme thoroghly using Chimera, VMD softwares. The structure of different ligand used was minimized using Argus Lab. Then using Molegro Virtual Docker software the docking study was performed.
In the recent times, IDPs have a new mark in the study of protein structure -function relationship. It has become evident that these proteins do not require a stable structure even under physiological conditions in order to do their biological role. A number of such proteins have been identified which lack a well -defined tertiary structure and exhibit a number of slighyly different conformations that dynamically change over time and population. In our work, we have chosen two completely different proteins: